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Site‐specific recombination in the immune system 1
Author(s) -
Lieber Michael R.
Publication year - 1991
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.5.14.1752360
Subject(s) - recombination , immune system , biology , repertoire , genetics , v(d)j recombination , computational biology , orchestration , evolutionary biology , gene , physics , acoustics , art , musical , visual arts
Site‐specific DNA recombination has been identified in a wide variety of biological systems. In vertebrates, however, the only identified use of this genetic device is in the immune system. Here it plays a critical role in generating a diverse repertoire of surface receptors to intercept invading microbes and parasites. The mechanism and orchestration of this reaction are intriguing and are relevant to a broad array of related biological and biomedical issues.— Lieber, M. R. Site‐specific recombination in the immune system. FASEB J. 5: 2934‐2944; 1991.