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RNA polymerase: regulation of transcript elongation and termination
Author(s) -
Kerppola Tom K.,
Kane Caroline M.
Publication year - 1991
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.5.13.1916107
Subject(s) - elongation , rna polymerase ii , transcription (linguistics) , elongation factor , rna , biology , rna processing , microbiology and biotechnology , polymerase , gene , computational biology , genetics , gene expression , promoter , ribosome , linguistics , materials science , philosophy , metallurgy , ultimate tensile strength
Expanded interest in studying the mechanisms of elongation and termination during transcription has come as a result of several recent findings that highlight the importance of the regulation of these processes in human health. Several cellular proto‐oncogenes contain regulated blocks to elongation (1), and the human immunodeficiency viruses also control gene expression in part by regulating the efficiency of elongation in response to the trans‐activating protein, TAT (2). This review considers these recent findings and compares potential mechanisms of regulation used by prokaryotic and eukaryotic RNA polymerases during elongation and termination. In all these systems, many of the detailed mechanisms of transcription elongation and termination are still to be defined; however, we have tried to group examples that may share some common regulatory elements into simplified categories.—Kerppola, T. K.; Kane, C. M. RNA polymerase: regulation of transcript elongation and termination. FASEB J. 5: 2833‐2842; 1991.