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Antigen specificity of γδ T lymphocytes
Author(s) -
Born Willi K.,
O'Brien Rebecca L.,
Modlin Robert L.
Publication year - 1991
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.5.12.1717333
Subject(s) - antigen , immunology , biology
γδ T cells represent a new lymphocyte subset without a definitive functional assignment. Although in many ways similar to αβ T lymphocytes, they are clearly distinguished by their expression of a different set of T cell receptor genes, a different distribution in normal tissues, and perhaps also different ligand specificities. Because γδ T cells appear to be involved in a variety of human diseases, the determination of their biological role has become an important challenge for immunologists and researchers in related areas.—Born, W. K.; O'Brien, R. L.; Modlin, R. L. Antigen specificity of γδ T lymphocytes. FASEB J. 5: 2699‐2705; 1991.