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Pathologic concentrations of interleukin 6 inhibit T cell responses via induction of activation of TGF‐β
Author(s) -
Zhou Daohong,
Munster Andrew,
Winchurch Richard A.
Publication year - 1991
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.5.11.1868982
Subject(s) - transforming growth factor , immunology , immune system , interleukin , t cell , cell , interleukin 4 , biology , cancer research , cytokine , medicine , endocrinology , genetics
Interleukin 6 levels are increased in a variety of clinical conditions including bacterial and viral infections, HIV infection, autoimmune diseases, certain neoplasias, and traumatic injury. In general, all these conditions are characterized by suppression of one or more manifestations of the immune response. Concentrations of IL 6 comparable to those found in the sera of immunosuppressed, thermally injured patients selectively inhibit T cell proliferative responses. This suppression is independent of IL 2‐mediated responses, is dependent on macrophage activity, and is reversed by antisera specific for transforming growth factor‐ β (TGF‐ β ).—Zhou, D.; Munster, A.; Winchurch, R. A. Pathologic demonstrations of interleukin 6 inhibit T cell responses via induction of activation of TGF‐ β . FASEB J. 5: 2582‐2585; 1991.