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Human chagasic IgG interacting with lymphocyte neurotransmitter receptors triggers intracellular signal transduction
Author(s) -
SterinBorda Leonor,
Gorelik Gabriela,
Genaro Ana,
Goin J. C.,
Borda E. S.
Publication year - 1990
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.4.6.2156743
Subject(s) - intracellular , muscarinic acetylcholine receptor , receptor , signal transduction , cholinergic , neurotransmitter receptor , microbiology and biotechnology , neurotransmitter , biology , lymphocyte , stimulation , immunology , chemistry , endocrinology , biochemistry
It is demonstrated that human IgG in Chagas' disease and the corresponding F(ab)‘2 fragment attach to lymphoid cells by specific interaction with β‐adrenergic and muscarinic cholinergic receptors. This interaction resulted in the transduction of signals that increased intracellular levels of cAMP in enriched T helper cell preparations and cGMP in enriched T suppressor cell preparations. The stimulation of Ts cell muscarinic cholinergic receptors by Chagas IgG or the corresponding F(ab)‘2 fraction triggers the release of the immunomodulatory substance PGE 2 . These results are unified in a theory of immunoregulation and could contribute to the chronic course of Chagas' disease.—S terin ‐B orda , L.; G orelik , G., G enaro , A.; G oin , J. C., B orda , E. S. Human chagasic IgG interacting with lymphocyte neurotransmitter receptors triggers intracellular signal transduction. FASEB J. 4: 1661‐1667; 1990.