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Movement of proteins through the Golgi stack: a molecular dissection of vesicular transport 1
Author(s) -
Rothman James E.,
Orci Lelio
Publication year - 1990
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.4.5.2407590
Subject(s) - golgi apparatus , vesicle , vesicular transport protein , clathrin , endocytosis , microbiology and biotechnology , transport protein , copi , clathrin adaptor proteins , chemistry , biology , secretory pathway , receptor , biochemistry , endoplasmic reticulum , membrane
A combination of cell‐free biochemical and morphological studies has revealed that a coated bud‐coated vesicle transport system shuttles newly synthesized proteins through the successive processing compartments of the Golgi apparatus. These Golgi‐coated vesicles operate in a manner formally analogous to the clathrin‐coated, pit‐coated vesicle system responsible for receptor‐mediated endocytosis; however Golgi‐coated vesicles do not contain clathrin.—R othman , J. E.; O rci , L. Movement of proteins through the Golgi stack: a molecular dissection of vesicular transport. FASEB J. 4: 1460‐1468; 1990.