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Inverse correlation between steady‐state RNA and cell surface T cell receptor levels
Author(s) -
Maguire Jean E.,
McCarthy Susan A.,
Singer Alfred,
Singer Dinah S.
Publication year - 1990
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.4.13.1698681
Subject(s) - t cell receptor , cd8 , thymocyte , microbiology and biotechnology , receptor , t cell , cell , rna , cd3 , population , biology , chemistry , immunology , biochemistry , antigen , gene , immune system , medicine , environmental health
The relationship between steady‐state RNA and cell surface levels of T cell receptor (TCR) was examined in mature T cells and immature CD4 + CD8 + double positive thymocytes. TCR is expressed at high levels on the surface of mature T cells and at much lower levels on double positive thymocytes. We demonstrate that in direct contrast to surface expression, TCR‐α, ‐β, CD3‐δ, ‐ϵ, ‐γ, and s RNA levels are much higher in the immature double positive thymocyte population than in mature T cells. These results demonstrate that quantitative differences in TCR surface expression in immature and mature T cells are not due to increases in TCR RNA levels.— M aguire , J. E.; M c C arthy , S. A.; S inger , A.; S inger , D. S. Inverse correlation between steady‐state RNA and cell surface T cell receptor levels. FASEB J. 4: 3131‐3134; 1990.