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Effects of spaceflight on the proliferation of jejunal mucosal cells
Author(s) -
Sawyer H. R.,
Moeller C. L.,
Phillips R. W.,
Smirnov K. L.
Publication year - 1990
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.4.1.2295380
Subject(s) - crypt , spaceflight , mitosis , biology , andrology , medicine , chemistry , immunology , endocrinology , anatomy , microbiology and biotechnology , physics , astronomy
The mitotic indices, villus heights, and crypt depths were determined in each of three jejunal regions (proximal, middle, and distal) for five animals each in the flight, vivarium, and synchronous groups. Because of the rapid turnover of intestinal mucosal cells and the delay in recovering the flight animals, it is not known whether the proliferation of jejunal mucosal cells is affected by microgravity conditions associated with spaceflight. However, since there were no consistent differences between animals in the flight group and those in the synchronous and vivarium control groups, it appears that any effects of microgravity on the turnover of jejunal mucosal cells are short‐lived. Thus, this study represents an initial step in determining the effects of microgravity on the proliferation and turnover of intestinal mucosal cells.—S awyer , H. R.; M oeller , C. L.; P hillips , R. W.; S mirnov , K. L. Effects of spaceflight on the proliferation of jejunal mucosal cells. FASEB J. 4: 92‐94; 1990.