Premium
Assessment of cardiac function during the progression of heart failure induced by intracoronary embolizations in the canine model: monitoring in conscious and anesthetized states.
Author(s) -
Krishnan Abhinav C,
Lovelace Abe,
Senador Danielle,
Kaur Jasdeep,
Alvarez Alberto,
Hanna Hanna W,
Levanovich Peter E,
Dombrowski Mary D,
Mannozzi Joseph T,
Aung Kimberly,
Haddad Samuel,
SalaMercado Javier,
Levy Phillip D,
O'Leary Donal S
Publication year - 2017
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.31.1_supplement.lb649
Subject(s) - medicine , embolization , heart failure , hemodynamics , ejection fraction , anesthesia , cardiology , cardiac output , occlusion , artery , cardiac function curve , surgery
Various animal models of acute and chronic heart failure exist including coronary artery occlusion via ligation or microembolization, rapid‐ventricular pacing, aortic banding, and fluid challenge. However, to our knowledge, no study has investigated whether anesthesia alters conclusions regarding hemodynamic effects associated with heart failure development. In this study, global ischemic cardiomyopathy, via repeated coronary artery microembolizations, (range: 5–15 embolization procedures per animal) was induced to lower ejection fraction to < 40% in ten chronically instrumented canines. We measured the progression of myocardial dysfunction over time, with each animal serving as its own control in conscious and anesthetized states to elucidate the effect of anesthesia on cardiovascular parameters. Hemodynamic measurements were taken in three conditions: anesthetized, immediately prior to each embolization, anesthetized 1.25 minutes after each embolization, and in a conscious, non‐anesthetized state at rest, 1 week after each embolization. We observed that anesthesia lowered arterial pressure (Δ−31.8 ±3.7%) and cardiac output (Δ−22.2 ±3.4%) when compared with the conscious state and that the effect of the embolization on ventricular function was better revealed in conscious animals. Thus, anesthesia affects the conclusions drawn regarding the extent of cardiovascular impairment induced via the embolization model. Support or Funding Information Supported by Novartis Pharmaceuticals CRLX030AUSNC01T and NIH HL55473 and HL126706.