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Role of Acyl‐CoA Short Chain Synthetase 2 and Acetyl‐CoA in Regulation of Chromatin Modifications and Gene Expression
Author(s) -
Lindahl Anastasia J.,
Moffett John R.,
Krishnan Jishnu K. S.,
Appu Abhilash,
Puthillathu Narayanan V.,
Krautkramer Kimberly,
Dowell James A.,
Namboodiri Aryan M. A.,
Denu John M.
Publication year - 2017
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.31.1_supplement.lb63
Subject(s) - chromatin , chromatin remodeling , histone , histone modifying enzymes , acetylation , epigenomics , biology , gene expression , microbiology and biotechnology , epigenetics , regulation of gene expression , histone code , gene , biochemistry , dna methylation , nucleosome
Post‐translational modifications of proteins control many complex biological processes, including genome expression, chromatin dynamics, metabolism, and cell division. Histone protein acetylation and methylation have been extensively linked to the regulation of chromatin remodeling and gene expression. Chromatin modifying enzymes utilize a variety of metabolites as co‐substrates to catalyze their respective chromatin modifications, closely linking chromatin modifications and metabolism. In this study, we have investigated the role of acyl‐CoA short chain synthetase family member 2 (ACSS2), the cytosolic and nuclear Acetyl‐CoA synthetase of the cell, in the regulation of histone and chromatin protein post‐translational modifications as well as gene expression through proteomic and genomic approaches. Support or Funding Information AJL was supported by NIH National Research Service Award T32 GM07215