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Evaluation of Diuretic and Urine Electrolyte Effects of Naringenin in Hypercholesterolemic Rats
Author(s) -
Madkhali Hassan Abdu,
Ganaie Majid Ahmad,
Ansari Mohammad Nazam,
Khan Tajdar Husain
Publication year - 2017
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.31.1_supplement.lb555
Subject(s) - diuretic , naringenin , medicine , endocrinology , urine , cholesterol , excretion , chemistry , urinary system , biochemistry , antioxidant , flavonoid
Hypercholesterolemia is a major risk factor in the incidence of many cardiovascular diseases and renal dysfunction. In the recent times, the natural compounds have received special attention for the treatment of the diseases due to their safety and low cost. Thus, the aim of our study was to investigate the possible diuretic and electrolyte effects of naringenin (50mg/kg and 100 mg/kg; orally) in hypercholesterolemic rats. Four groups of Wistar rats were used (6 in each group): group I, the normal control rats fed with normal pallet diet; group II, rats fed with 1% cholesterol diet for 4 weeks; group III, rats fed with 1% cholesterol diet and concomitantly treated daily with naringenin 50mg/kg orally for 4 weeks; group IV, rats fed with 1% cholesterol diet for 4 weeks and concomitantly treated daily with naringenin 100mg/kg orally for 4 weeks. Urine volume was recorded for each group after 5 hrs and 24 hrs of the last dose of treatment. Serum and urine samples of all the groups were collected and tested for serum total cholesterol and urine electrolytes. Hypercholesterolemia in rats resulted in significantly increased serum cholesterol level and decreased in urinary volume (ml) and electrolytes (sodium, potassium and chloride ions) excretion. Oral administration of naringenin significantly restore the altered parameters in hypercholesterolemic rats. The current study investigated the diuretic and urinary electrolyte effects of naringenin in hypercholesterolemic rats. Our result suggest a beneficial role for naringenin in restoring the water and electrolyte balance in hypercholesterolemia induced cardiovascular and renal dysfunction.