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Progressive aging changes in the optical properties of Rat brain
Author(s) -
Shi Lingyan,
Sriramoju Vidyasagar,
Kaleem Asma,
Dudley Raymond,
RodriguezContreras Adrian,
OstosValverde Aline,
Alfano Robert R
Publication year - 2017
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.31.1_supplement.lb521
Subject(s) - chromophore , fluorescence , cerebral cortex , biophysics , absorption (acoustics) , brain cortex , neuroscience , cortex (anatomy) , chemistry , endocrinology , medicine , biology , photochemistry , materials science , optics , physics , composite material
The objective of this study to investigate how molecular changes caused by aging effects the absorption and fluorescence of cerebral cortex during the postnatal development in the rat. The aging dependent changes in the absorption and fluorescence properties of native chromophores in rat cerebral cortex were studied at postnatally from neonatal stage to adulthood at days 5,10, 15, and 45. The primary chromophores in brain are responsible for specific absorption and/or fluorescence emission are collagen, tryptophan, NADH, flavins and water. The evolution in the relative concentrations of these key chromophores in the rat brains progressively with increasing age is presented. Understanding changes in the optical properties with age will help in developing better understanding the underlying development of molecular components in the brain and for imaging strategies for methods like optical tomography and multiphoton brain imaging.