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Analysis of Serum Ferritin and High Sensitive C Reactive Protein in Patients with Gout
Author(s) -
Ma Aiguo,
Wei Jingyan,
Zhang Huaqi,
Wu Dayong
Publication year - 2017
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.31.1_supplement.lb414
Subject(s) - medicine , hyperuricemia , gout , c reactive protein , ferritin , uric acid , confounding , triglyceride , gastroenterology , endocrinology , cholesterol , inflammation
Objective The relationship between serum concentrations of ferritin and high sensitive C reactive protein in men and the risk of gout was unclear. Methods In this study we enrolled 600 male patients diagnosed with gout, 600 male patients with hyperuricemia, and 600 male health people as the control. The information of physical examination and related indicators was collected in all three groups, including height, weight, serum ferritin (SF), high sensitive C reactive protein (hs‐CRP), uric acid (UA), fasting blood glucose (FPG), triglyceride (TG), and total cholesterol (TC). Results The average concentration of serum ferritin (SF) was higher in gout group (135.27 μg/L) than in hyperuricemia group (114.45μg/L, p <0.05), and the control group (76.02 μg/L, p <0.05); the mean level of hs‐CRP in gout patients was 0.3 mg/dl, significantly higher than that in hyperuricemia group (0.13mg/dl) and the control group (0.09mg/dl) (all P <0.05). After adjusting for age, BMI, TG, TC, FPG and other confounding factors, SF levels were positively correlated with hs‐CRP levels in hyperuricemia group and gout group, while there was no association between SF and hs‐CRP levels in the control group. The multivariate logistic regression analysis showed that after adjusting for BMI, TG, TC, FPG, UA and other confounding factors, the high levels of SF (≥155.78ug/l) significantly increased risk of gout, with OR of 2.678 (95% CI , 1.484–4.833); higher levels of hs‐CRP (>0.9mg/dl) was also a risk factor of gout, with OR of 3.104 (95% CI , 1.727–5.580). Conclusion Serum concentrations of ferritin level and high sensitive C reactive protein were significantly elevated in patients with gout. These results suggest that hs‐CRP, and SF may be involved in the pathogenesis of gout; however, whether it can be used as a predictor of gout attack needs further study. Support or Funding Information The National Natural Science Fund (No. 81373000)