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Impact of breast cancer diagnosis, personal characteristics and lifestyle factors on depressive symptoms
Author(s) -
Judge Michelle Price,
Julian Thomas,
Wu Jing,
Walter Jeanne,
Irvin William J.,
Starkweather Angela
Publication year - 2017
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.31.1_supplement.lb327
Subject(s) - medicine , breast cancer , depression (economics) , cohort , cancer , psychological intervention , anxiety , alcohol consumption , gerontology , clinical psychology , psychiatry , alcohol , biochemistry , chemistry , economics , macroeconomics
Breast cancer (BCA) is associated with risk of an array of psychoneurological symptoms (PNS) including disturbances in sleep, anxiety, and depression. Lifestyle factors and personal characteristics, with potential impact on PNS, remain largely unexplored. METHODS A secondary exploratory analysis was conducted evaluating depressive symptoms in a cohort of women with stage I or II BCA during treatment for BCA and non‐BCA controls (n=58). Center for Epidemiologic Studies Depression Scale (CES‐D) assessments were observed at 3 time points (baseline, month 4 and month 9). With generalized linear mixed model and estimating equation approach the impact of cancer diagnosis, age, alcohol consumption, race, smoking, and BMI was evaluated related to CES‐D score. RESULT Breast cancer diagnosis (p=0.0298), smoking (p=0.0002), and mixed race identity (>1 race, p=0.0069) were significant predictors of CES‐D score. Age, alcohol consumption and BMI were not significant. CONCLUSION Women undergoing active treatment for BCA were at elevated risk for depressive symptoms supporting a need for more extensive evaluation and interventions for depressive symptoms during treatment for BCA. Additionally, smoking and mixed race identity, predictive of depressive symptoms, may compound risk in women with BCA. Further work is necessary evaluating the association of dietary factors with BCA depressive symptomatology. Support or Funding Information Research reported in this publication was supported by the National Institute of Nursing Research of the National Institutes of Health under Award Number P30NR011403. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.