Premium
Higher serum carotenoid concentration associated with a lower incidence of metabolic syndrome in middle‐aged and elderly Chinese adults
Author(s) -
Chen Yuming,
Wang Cheng,
Qiu Rui,
Chen Gengdong,
Cao Yi,
Zeng Fangfang
Publication year - 2017
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.31.1_supplement.lb315
Subject(s) - carotenoid , zeaxanthin , lutein , medicine , metabolic syndrome , lycopene , waist , incidence (geometry) , quartile , confounding , blood lipids , population , physiology , body mass index , cholesterol , obesity , food science , confidence interval , biology , environmental health , physics , optics
Background Several epidemiological studies revealed associations between carotenoids and the metabolic syndrome (MetS), but limited longitudinal cohort studies have been conducted to regard this association. Objective The objective of this study was to investigate whether serum carotenoids predict the incidence of the Mets and what is accounted for the associations by changes of lipids in a large population‐based study. Method We conducted a follow‐up study on 2773 men and women aged 40–75 years without Mets at baseline from the Guangzhou Nutrition and Health Study (GNHS). Blood pressure, waist circumference, blood lipids, glucose and other covariates data were collected in average every 3 years surveys. Serum carotenoids (α‐, β‐carotene, β‐cryptoxanthin, lycopene and lutein/zeaxanthin) were examined by HPLC at baseline. Results Over the average 5.4 years follow‐up, 1979 subjects with serum carotenoids assessed at baseline took part in the follow‐up survey at least once and 554 subjects developed new MetS during the follow‐up period. Inverse associations between serum carotenoids and the incidence of MetS were observed. After adjustments for confounders, HRs (95% CIs) of MetS for the highest (v.s. the lowest) quartile were 0.72(0.57, 0.90) for lutein/zeaxanthin, 0.39 (0.31, 0.51) for lycopene, 0.42 (0.32, 0.54) for α‐carotene, 0.45 (0.34, 0.56) for β‐carotene and 0.47(0.37, 0.61) for total carotenoids (all P ‐trend <0.05). Other significant favorable associations between changes of HDLc with serum carotenoids were also revealed. Conclusion Our results revealed associations between higher serum carotenoid levels and a lower incidence of MetS in Chinese adults and the favorable influence of carotenoids might be partially driven by an improvement of serum HDLc. Support or Funding Information The present study was jointly supported by the National Natural Science Foundation of China (81472965, 81130052) and by the 5010 Program for Clinical Researches (No. 2007032) of the Sun Yat‐sen University (Guangzhou, China)