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Dietary Pattern's Association with Incident Parkinsonism and Progression of Parkinsonian Signs with Aging
Author(s) -
Agarwal Puja,
Wang Yamin,
Buchman Aron S,
Morris Martha C
Publication year - 2017
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.31.1_supplement.lb309
Subject(s) - parkinsonism , medicine , cohort , hazard ratio , cohort study , proportional hazards model , physical therapy , disease , pediatrics , psychology , confidence interval
Half of the elderly population by 85 years of age develop mild parkinsonian signs that are progressive with time and are associated with disability and mortality. There are limited studies on how diet may relate to incident Parkinsonism and the progression of this common condition in the elderly. This analysis aims to identify the association of MIND, Mediterranean and DASH dietary patterns with incident Parkinsonism and the progression of parkinsonian signs in older adults. Methods A total of 808 participants from the Rush Memory and Aging Project (an ongoing longitudinal cohort study) were assessed annually over 12 years of follow‐up. Parkinsonism was defined as having 2 or more Parkinsonian signs. A trained nurse clinician assessed Parkinsonian signs scores using the modified version of United Parkinson's Disease Rating Scale, including 26‐items that assess four separate signs: Bradykinesia, Gait, Rigidity, and Tremor. MIND, Mediterranean and DASH diet scores were computed using a food frequency questionnaire administered at baseline. Participants with Parkinson's disease at baseline, missing or invalid food frequency questionnaire and less than two Parkinsonian signs assessments were excluded. Incident Parkinsonism was assessed by Cox‐Proportional Hazard ratio. A linear mixed model with random effects was used for Parkinsonian signs scores (square root transformed). All models were adjusted for age, sex, smoking, total energy intake; mixed models were also adjusted for time and its interaction term with covariates. Results All three dietary patterns had inverse relation with the risk of Parkinsonism (MIND score (HR=0.87, 95% CI 0.80–0.94), Mediterranean score (HR=0.97, 95% CI 0.94–0.99), and DASH score (HR=0.91, 95% CI 0.83–0.99)). The progression of Parkinsonian signs score was negatively associated with MIND score (β= −0.009; SE=0.0036; p=0.01), Mediterranean score (β= −0.003; SE=0.0013; p=0.02) and DASH score (β= −0.010; SE=0.0046; p=0.03). With further adjustment for depression and BMI, only the MIND diet remained statistically significant for both incident Parkinsonism and progression of Parkinsonian signs. In the final model standardized β coefficients of the estimated diet effects on Parkinsonian signs scores were −2.22 for MIND, −1.75 for Mediterranean and −1.65 for DASH diet. Discussion MIND, Mediterranean and DASH dietary patterns are associated with decreased risk of Parkinsonism and may slow the progression of Parkinsonian signs with age. Support or Funding Information R01AG054057 and Consolidated Anti‐aging Foundation