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Drug Delivery in the Eye
Author(s) -
Hosten Justin,
Penumutchu Swathi,
Lavik Erin
Publication year - 2017
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.31.1_supplement.lb239
Subject(s) - plga , drug , medicine , pharmacology , drug delivery , optic nerve , ophthalmology , nanotechnology , nanoparticle , materials science
On average, 1.4 million Americans suffer a head related injury every year. Of these injuries many can result in eye injury, in particular retinitis pigmentosa(RP). Recent innovation has lead to the creation of biodegradable microspheres and nanoparticles. One such use of these spheres/particles is to be a carrier for various drugs and be used for delivery to the human body, where oral drugs fail. For optic nerves, the blood brain barrier, which protects the brain from various chemicals that could have major negative effects, blocks many oral drugs from reaching the area where they are located. This poses a problem from optic related injuries. The drug All‐Trans Retinoic Acid (ATRA), is a compound that has the ability to repair damaged optic nerves. This drug can be loaded and directed to the optic nerves through poly (lactic‐co‐glycolic acid) (PLGA) microspheres. PLGA is a biodegradable polymer that allow for control and targeted release for various drugs. We hypothesize that loading ATRA with the addition of a co solvent, trifluoroethanol (TFE), methanol, and acetone, will increased the amount of ATRA within the microspheres, due to the hydrophilic properties of ATRA. This increased loading of the drug will allow for sustained release over long person of time, improve patient compliance, and patient treatment. Support or Funding Information Funded by NIH and Glaucoma Foundation