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Strategies for Point‐of‐Care Detection of Nucleic Acid Targets
Author(s) -
Broyles David,
Deo Sapna K.
Publication year - 2017
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.31.1_supplement.lb130
Subject(s) - point of care , multiplexing , health care , computer science , schedule , miami , point of care testing , risk analysis (engineering) , miniaturization , engineering management , medicine , engineering , telecommunications , pathology , electrical engineering , political science , environmental science , soil science , law , operating system
In order avoid complex detection platforms that require sophisticated equipment and trained personnel, point‐of‐care assays must incorporate technology that involves minimal user interaction and easily detectable output while maintaining high sensitivity and selectivity. In addition, the ability to provide multiplexed output can increase device utility and save valuable time for healthcare providers. Rather than rely upon miniaturization of current technology, we are attempting to provide low‐cost substitutes for laboratory tests that can provide the end user sufficient information to accurately diagnose and treat diseases and infections without waiting for traditional laboratory testing or having to schedule follow‐up appointments. Support or Funding Information This work was supported by grants from the National Science Foundation (CHE‐0748648) and the National Institutes of Health (EB008231‐01). The authors would like to thank the Department of Biochemistry and Molecular Biology at the University of Miami – Miller School of Medicine.