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Evaluation of anti‐obesity activity of different extracts from Grifola frondosa in vitro
Author(s) -
Lin PeiShan,
Huang ChinShiu,
Huang PeiJane,
Han ChienKuo,
Chen HsiaoLing
Publication year - 2017
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.31.1_supplement.974.19
Subject(s) - grifola frondosa , chemistry , obesity , christian ministry , ethanol , in vitro , traditional medicine , food science , lipase , biochemistry , pharmacology , biology , enzyme , endocrinology , medicine , mushroom , philosophy , theology
Grifola frondosa have been reported to have hypolipidaemic effects and several health benefits. However, the anti‐obesity activity and the optimal extract underlying these actions of G. frondosa have not been reported. In this study, we screened seven different extracts from G. frondosa to test their anti‐obesity activity using porcine pancreatic lipase assay in vitro activity. We also investigated the inhibitory effects of G. frondosa extracts on lipid droplet accumulation and cell growth during 3T3‐L1 preadipocyte differentiation. The lipase inhibitory activities of these seven extracts of G. frondosa were higher in the 50% ethanol extract than in other extracts. The 50% ethanol extract from G. frondosa also had highest inhibitory activity on cell growth and lipid accumulation during 3T3‐L1 cell differentiation. These results suggest that 50% ethanol extract of G. frondosa may have potential benefits as a health agent with anti‐obesity properties. Support or Funding Information This study was supported by a grant (MOST‐105‐2632‐B‐468‐001) from the Ministry of Education, Republic of China (Taiwan).