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Gelidium elegans Extracts Improve Insulin Sensitivity in C57BL/KsJ m+/+db Mice and C57BL/KsJ‐db/db Mice
Author(s) -
Choi SeoYun,
Choi Jia,
Koh EunJeong,
Seo YoungJin,
Song JiHyeon,
Hwang JiHyeon,
Lee YeonJoo,
Chei Sungwoo,
Park MinKi,
Lee BooYong
Publication year - 2017
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.31.1_supplement.974.12
Subject(s) - chemistry , insulin , medicine , endocrinology , cholesterol , insulin sensitivity , biology , biochemistry , insulin resistance
Gelidium elegans is a species of red algae that mostly grows in the northeastern Sea of Asia. Recent research using 3T3‐L1 adipocytes suggests that the ethanol extract of Gelidium elegans may have anti‐obesity effects. Specifically, reported that Gelidium elegans contains various flavonoids, including hesperidin, which has an anti‐obesity effect. Gelidium elegans extracts exert an anti‐diabetic effect in C57BL/KsJ‐db/db mice. Gelidium elegans extracts supplementation significantly reduced bodyweight, water intake, fasting blood glucose, and plasma insulin levels compared with db/db mice. In additiona biomarker of insulin secretion, was significantly decreased by Gelidium elegans extracts treatment. Regarding plasma lipid profiles, triacylglycerol, total cholesterol, and low‐density lipoprotein (LDL) cholesterol, were effectively reduced in the Gelidium elegans extracts treated groups. This result showed that Gelidium elegans extracts regulate blood glucose levels by improving insulin sensitivity in the diabetic condition. Our data suggest that Gelidium elegans extracts may be anti‐diabetic agents.