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Gamma‐Oryzanol in Rice Bran Oil Play a Significant Role in the Anti‐inflammatory Action by Modulating NF‐κB p65 Translocation and Reducing the Expression of Inflammatory Markers in Rat Peritoneal Macrophages
Author(s) -
Yalagala Poorna Chandra Rao,
Dhavamani Sugasini,
Lokesh Belur R.
Publication year - 2017
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.31.1_supplement.972.10
Subject(s) - rice bran oil , chemistry , bran , food science , proteases , chromosomal translocation , monocyte , biochemistry , biology , enzyme , immunology , gene , raw material , organic chemistry
Dietary Rice bran oil (RBO) is reported to exhibit anti‐inflammatory activity by inhibiting the activation of NF‐κB p65. However the role of γ‐Oryzanol (γ‐ORY), ferulic acid esters present in RBO in this process is not well established. To study this, male Wister rats were fed AIN‐93 diet containing RBO with γ‐ORY (RBO‐N), Minor Constituents Removed RBO (RBO‐MCR), RBO‐MCR supplemented with Unsaponifiable Fraction from Rice Bran Oil (UFRBO), RBO‐MCR supplemented with γ‐ORY, for a period of 60 days. The macrophages form rats fed a diet containing RBO with oryzanol or RBO –MCR supplemented with γ‐ORY or with UFRBO showed significant down‐regulation in the expression of NF‐κB p65, and that of inflammatory markers such as Matrix Metallo Proteases (MMP‐9) and Monocyte Chemoattractant Protein (MCP‐1) as compared to those fed diet containing RBO‐MCR. The present study indicated that pure γ‐ORY or ORY present in unsaponifiable fraction of RBO contributes to the anti‐inflammatory action of dietary RBO by inhibiting the translocation of NF‐κB p65 and down‐regulating the levels pro‐inflammatory markers. Support or Funding Information CSIR‐CFTRI