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Changes in Body Mass Index (BMI) and Lipid Profile in Healthy Mice with Consumption of Omega‐3 Fatty Acids Extracted from Microalgae
Author(s) -
MartínezCarrillo Beatriz Elina,
GutiérrezPliego Laura Elisa,
EscotoHerrera Jorge Alberto,
ValdésRamos Roxana
Publication year - 2017
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.31.1_supplement.971.26
Subject(s) - lipid profile , fatty acid , distilled water , chemistry , body mass index , food science , omega 3 fatty acid , palmitic acid , fish oil , zoology , biochemistry , biology , endocrinology , polyunsaturated fatty acid , cholesterol , chromatography , docosahexaenoic acid , fish <actinopterygii> , fishery
The consumption of omega‐3 fatty acid extracted from fish oil and its health effects has been extensively studied, however the new technologies used to extract these fatty acids from microalgae as a sustainable omega‐3 source has generated new questions about the possible beneficial health effects. The aim of this study was to evaluate the effect of consumption of omega‐3 fatty acids extracted from microalgae on BMI and lipid profile in healthy mice. We used 24 CD1 mice, 8‐weeks old divided into 4 groups: Control (CL), Modified chow (MCH), Lyophilized (LI) and Saturated Fatty acid (SAT). MCH group was fed ad libitum with a normal diet with 2.9% of Omega‐3 microalgae added; LI and SAT group were daily orally supplemented with Omega‐3 lyophilized microalgae (1 mg / g weight + distilled water to a final volume of 100ml per day) and coconut oil (1 mg / g weight) respectively and were fed with a normal diet. Study was conducted through 8 th to 16 th weeks of life. BMI, peripheral blood glucose, chow and water intake, and lipid profile was quantified. No differences in final BMI were found. Blood glucose concentration showed differences between groups only at 10 th week of life (F=4.572, p<0.014) being GSAT lower than LI (p<0.01). Chow and water intake showed differences between groups at the 16 th week of life (F=7.669, p<0.001 and F= F= 116.766, p<0.01 respectively) being MCH lower than LI and SAT (p<0.001 for both groups) for chow and water intake. For lipid profile; total cholesterol, high density lipoprotein (HDL‐c), low density lipoprotein (LDL‐c), very low density lipoprotein (VLDL‐c) and triglycerides were quantified. Total cholesterol and LDL‐c showed no differences between groups, HDL‐c showed differences between groups (F=4.665, p<0.05) being MCH group lower than LI (p<0.02) and GSAT (p<0.032). VLDL‐c showed differences between groups (F=12.108, p<0.01) being LI lower than CL (p<0.001) and GSAT (p<0.011), Triglycerides concentration were different between groups (F=12.626, p<0.01) being LI lower than CL (p<0.01) and GSAT (p<0.01). The results of this study suggest that omega‐3 fatty acids from microalgae have a beneficial effect on VLDL‐c and triglyceride concentrations and do not cause significant modifications on BMI. Support or Funding Information We thank Biotecnología Mexicana de Microalgas Company (Biomex) and CONACyT 1Total Cholesterol, high density lipoprotein (HDL‐c), low density lipoprotein (LDL‐c), very low density lipoprotein (VLDL‐c) and triglycerides of CD1 mice. Values represent Mean± SD. One‐way ANOVA was performed to compare differences between groups; differences were considered significant at p<0.05, Bonferroni post hoc test shows intragroup differences; Control (CL), Modified chow (MCH), Lyophilized (LI) and Saturated Fatty acid (SAT).