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Serum and Brain Fatty Acid Profile of Growing Rats Feed With High‐Dietary Lipid Concentration from Different Sources.
Author(s) -
Perris Paula Daniela,
Fernandez Inés,
Mambrin María Cecilia,
Pellegrino Néstor,
Slobodianik Nora,
Feliu María Susana
Publication year - 2017
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.31.1_supplement.971.24
Subject(s) - weanling , sunflower oil , oleic acid , fatty acid , soybean oil , lipid profile , chemistry , food science , sunflower , brain development , palmitic acid , biochemistry , zoology , medicine , biology , endocrinology , cholesterol , agronomy , neuroscience
A balanced diet is important to maintain an optimal health status, to prevent chronic diseases. Diet lipid profile is important for the growth and development of the nervous system during the different stages of life. The central nervous system consists predominantly of lipids, much of them, they are composed of fatty acids, which cannot be synthesized by the body and must be supplied by diet. The ω3 and ω6 fatty acids are determinants in the development of the brain. Objetive analyze the effect of high dietary lipid concentration from different sources, on serum and brain fatty acid profile. Methods Weanling Wistar rats were fed during 40 days diet containing 42Kcal of lipids% provided by: butter (B); Olive oil (O); high oleic acid sunflower oil (HO) and sunflower oil (S). Control group (C) received normocaloric diet (soy oil, 15Kcal of lipids%;) according to AIN'93. Serum and brain fatty acids profile were determined by gas chromatography. Statistical analysis: Dunnett (*p<0.01). Results, expressed as %Area±SD, were: PALMITIC SERUM B:20,63±2,54*▲ O:18,23±1,09 HO:12,96±2,99 S:15,83±1,48 C:16,08±2,15 BRAIN B:16,89±1,61 O:17,35±4,12 HO:20,94±1,87 S:19,35±1,32 C:18,69±1,44, OLEIC SERUM B:20,37±2,23*▲ O:21,03±2,41*▲ HO: 26,96±3,71*▲ S:11,46±3,86 C:11,29±2,27 BRAIN B:19,63±6,30 O:18,45±6,82 HO:15,53±1,26 S:14,31±0,99 C:13,00±1,76 LINOLEIC SERUM B:9,79±1,12*▼ O:14,59±1,09 HO:7,41±1,89*▼ S:30,87±2,58*▲ C:18,50±3,31 BRAIN B:0,96±0,40 O:1,26±0,43 HO:0,40±0,04 S:1,21±0,24 C:1,00±0,20 LINOLENIC SERUM B:0,44±0,14*▼ O:0,29±0,05*▼ HO:0,32±0,13*▼ S:0,28±0,05*▼ C:0,81±0,22 BRAIN B:0,24±0,09 O:0,24±0,05 HO:0,24±0,02 S:0,26±0,09 C:0,34±0,09. Conclusions B, O y HO groups showed higher serum oleic acid levels with decrease of essential fatty acids levels compared to C. This fact would exacerbate the route of the ω9 family. On the other hand, S group presented in serum low linolenic acid values and high linoleic acid levels. In all groups the changes presented in serum were not observed in brain. These results suggest that the body tries to compensate the brain essential fatty acids needs at expense of its modification in serum. These changes observed were in response to differences in the sources of dietary lipids. Support or Funding Information UBACyT 20020150100011BA