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Acute Effects of a Beverage Containing Bitter Melon Extract (CARELA®) on Postprandial Glycaemia among Prediabetic Adults
Author(s) -
Boone Carleigh,
Stout Jeffrey,
Gordon Joseph,
Redd Michael,
Church David,
Oliveira Leonardo,
Fukuda David,
Hoffman Jay
Publication year - 2017
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.31.1_supplement.970.13
Subject(s) - postprandial , medicine , glycemic , ingestion , endocrinology , area under the curve , confidence interval , glucose tolerance test , prediabetes , plasma glucose , diabetes mellitus , glycemic index , impaired glucose tolerance , insulin , insulin resistance , type 2 diabetes
Acute ingestion of bitter melon (BM) has been shown to suppress the postprandial glycemic response in diabetics, but its impact on glucose regulation among individuals with impaired glucose tolerance is unclear. Moreover, one's glucose tolerance level may influence the effectiveness of BM. This study aimed to examine the acute effects of a beverage containing BM extract on blood glucose regulation during an oral glucose tolerance test (OGTT) among prediabetics. Methods Ten prediabetic adults completed two OGTTs ‐ glucose only (D2) and glucose + BM (D3). Responders were identified as subjects whose area under the glucose curve (AUC glu ) during D3 was lower than D2. To compare the acute effects of the beverage among individuals with varying glucose tolerance levels, subjects were grouped by their glucose response pattern – Fast peak (peak glucose (Glu peak ) at 30 min post‐glucose (30P)) and Slow peak (Glu peak after 30P). Results During D3, responders ( n = 5) experienced a 13.2% reduction in AUC glu (95% confidence interval (CI): −18.1% to −8.3%), 12.2% reduction in mean glucose (95% CI: −17.3% to −7.0%), and 10.6% reduction in Glu peak (95% CI: −17.5% to −3.7%); plasma glucose was reduced by 9.1% at 30P (95% CI: −15.6% to −2.6%), −24.0% at 60P (95% CI: −36.8% to −11.2%), and −20.0% at 90P (95% CI: −35.8% to −4.2%) during D3. No between‐trial differences were noted for Fast peak or Slow peak . Conclusions Acute ingestion of BM prior to the second OGTT (D3) led to a reduced postprandial glucose response in 50% of the subjects but did not affect the insulin response. Furthermore, the effectiveness of the beverage was seemingly uninfluenced by the subjects' glucose tolerance level. While BM has shown to aid blood glucose management in diabetics, it remains uncertain why only a portion of subjects responded positively to the BM extract in the current study.