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Anti‐inflammatory effects of Pleurotus eryngii (mushroom) in the colon: role of gut microbiota
Author(s) -
Yuan Biao,
Gu Min,
Han Yanhui,
Ma Gaoxing,
Hu Qiuhui,
Xiao Hang
Publication year - 2017
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.31.1_supplement.968.8
Subject(s) - pleurotus eryngii , mushroom , gut flora , inflammatory bowel disease , pleurotus , antioxidant , colitis , food science , inflammation , feces , biology , medicine , immunology , microbiology and biotechnology , disease , biochemistry
For many centuries, edible mushrooms have been used as functional and medicinal foods for various health benefits around the world. In this study, the protective effects of Pleurotus eryngii mushroom against inflammatory bowel disease (IBD) were determined in the dextran sulfate sodium (DSS)‐treated mice. Dietary administration of freeze‐dried mushroom powder alleviated colonic inflammation induced by DSS in mice, which was evidenced by decreased disease index, increased colon length, and reduced production of pro‐inflammatory cytokines such as IL‐1β, IL‐6, and TNF‐α in the colonic tissues. Sequencing the V3–V4 region of the 16S ribosomal RNA genes of microbiota demonstrated that DSS treatment significantly altered the composition of fecal microbiota, which correlated with exacerbated colonic inflammation in DSS‐treated mice. Interestingly, dietary treatment with mushroom partially reversed the alteration of fecal microbiota induced by DSS treatment. Furthermore, the levels of short chain fatty acids and antioxidant capacity of colonic contents were significantly increased by dietary P. eryngii mushroom in DSS‐treated mice. Overall, our results for the first time demonstrated anti‐inflammatory effects of P. eryngii mushroom in the colon, and their association with altered gut microbiota. Support or Funding Information This research work was funded by the National Natural Science Foundation of China under Grant No. 31471927.