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Serum vitamin D levels in individuals with polycystic ovary syndrome (PCOS), with or without non‐alcoholic fatty liver disease (NAFLD).
Author(s) -
Goktas Zeynep,
Atilgan Zeynep Tugba Donmez
Publication year - 2017
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.31.1_supplement.968.6
Subject(s) - medicine , polycystic ovary , fatty liver , insulin resistance , nonalcoholic fatty liver disease , body mass index , metabolic syndrome , vitamin d and neurology , gastroenterology , obesity , endocrinology , abdominal ultrasonography , disease , ultrasonography , surgery
Nonalcoholic fatty liver disease (NAFLD) has an increasing prevalence in patients with polycystic ovary syndrome (PCOS). Although PCOS is considered as a reproductive disorder, it is also a metabolic disorder due to its involvement in insulin resistance. Obesity and insulin resistance are the main factors related to NAFLD in PCOS. The purpose of this study was to assess NAFLD status in PCOS and analyze vitamin D serum levels in fertile individuals diagnosed with PCOS. A total of 68 female subjects, between the ages of 18 to 38, were recruited to the study. All the subjects were diagnosed with PCOS according to 2003 Rotterdam Revised Consensus by a gynecologist. A questionnaire evaluating general characteristics, physical activity and nutritional habits was administered by a trained dietitian. Abdominal ultrasonography was administered by a radiologist for NAFLD diagnosis. Blood samples were collected. Elecsys® Vitamin D total kits (Roche, Switzerland) were used to analyze the serum vitamin D levels. A total of 35 subjects (48.5%) was diagnosed with NAFLD. Mean serum vitamin D level was deficient at 11.7 ± 5.57 ng/mL however, vitamin D levels were not significantly different between subjects without NAFLD and subjects with NAFLD (10.5 ± 5.74 ng/mL and 13.0 ± 5.17 ng/mL, respectively, p>0.05). Mean Body Mass Index (BMI) was 31.8 ± 6.07 kg/m 2 and BMI was significantly higher among subjects with NAFLD than subjects without NAFLD (34.9 ± 5.45 kg/m 2 and 28.9 ± 5.13 kg/m 2 , respectively, p<0.001). Serum vitamin D levels did not significantly differ among subjects with normal vitamin D levels, subjects with insufficient vitamin D levels and subjects with deficient vitamin D levels. In this study, vitamin D level is observed to be <20ng/mL in 91.6% of the individuals having PCOS. NAFLD and vitamin D insufficiency seem to be common disorders among individuals with PCOS. Individuals with PCOS should be examined in terms of NAFLD and serum vitamin D levels.