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Relationship between Levels of Serum Methylglyoxal and Fasting Plasma Glucose in Blacks with and without Type 2 Diabetes
Author(s) -
Chantarasinlapin Praew,
Zarini Gustavo G.,
Barbieri M. Alejandro,
Wu Wensong,
Huffman Fatma G.
Publication year - 2017
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.31.1_supplement.966.4
Subject(s) - methylglyoxal , medicine , type 2 diabetes , diabetes mellitus , endocrinology , plasma glucose , prediabetes , chemistry , enzyme , biochemistry
Methylglyoxal is a dicarbonyl compound that has been reported to be associated with insulin resistance, diabetes, and other chronic illnesses. However, such observation among Black populations, including African Americans and Haitian Americans, remains scarce. PURPOSE The current study aimed to investigate the relationship between levels of serum methylglyoxal and fasting plasma glucose in African American and Haitian American participants, with and without type 2 diabetes. METHODS Participants were recruited by community outreach in Broward and Miami‐Dade counties, Florida. The study included a total of 488 eligible participants (n = 234 controls and n = 254 cases) over 30 years of age who had complete data of serum methylglyoxal and fasting plasma glucose. Serum levels of prominent methylglyoxal adduct, methylglyoxal hydroimidazolone 1 (MGH1) were measured by using a commercially available competitive ELISA kit. Fasting plasma glucose levels were determined by hexokinase enzymatic methods. Multiple linear regression analysis was used to examine the association of natural log‐transformed MGH1 and fasting plasma glucose. RESULTS There was an increase in MGH1 levels of 0.23% for every 1% increase in fasting plasma glucose levels, after adjusting for pertinent variables (95% CI [0.01%, 0.46%], p =0.042). However, such association was not found in participants without type 2 diabetes ( p =0.954). Interestingly, the geometric mean of MGH1 levels for African Americans with type 2 diabetes was about 20% lower than that for Haitian Americans with type 2 diabetes, holding other variables constant (95% CI [2.37%, 34.43%], p =0.028). CONCLUSION The findings suggest that methylglyoxal may be linked to hyperglycemia and metabolic changes in type 2 diabetes, and may differentially impact the development of the disease in Blacks. Support or Funding Information Funding for this research was provided through NIH/NIDDK sponsored grant #SC1DK083060.