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Morphofunctional changes of the left ventricle induced by the consumption of high carbohydrate diet
Author(s) -
Kitawara Koody Andre Hassemi,
Ribeiro Elisabeth Aparecida,
Francisqueti Fabiane Valentini,
Ferron Artur Junio Togneri,
Minatel Igor Otávio,
Bazan Silméia Garcia Zanati,
Anjos Ferreira Ana Lúcia,
Corrêa Camila Renata
Publication year - 2017
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.31.1_supplement.966.26
Subject(s) - ventricle , interventricular septum , diastole , medicine , cardiology , diastolic function , mass index , body mass index , blood pressure
Aim To evaluate the effect of the consumption of a high carbohydrate diet on the morphology and function of the left ventricle (LV). Methods 40 male Wistar rats were assigned to receive water + standard diet (group C, n=20) or CHO diet with water + 25% sucrose (CHO group, n=20) for 20 weeks. Food consumption (FC) was measured daily and body weight (BW) was assessed weekly. After 20 weeks, the following cardiac structures were measured: left ventricle diastolic (LVDD) and systolic diameter (LVSD); posterior wall diastolic (PWTd) and systolic thickness (PWTs); interventricular septum wall diastolic (SWTd) and systolic thickness (SWTs); aortic diameter (AD); left atrium diameter (LA); relative thickness of LV (RTLV); LV mass (LVM) and LV mass index (LVMI) were calculated by normalizing the LVM to the body weight. The systolic function was evaluated by the following indices: Percentage of endocardial shortening (% Δendo), percentage of mesocardial shortening (% Δ meso), posterior wall shortening velocity (PWSV). The diastolic LV function was evaluated by the following indices: Peak of initial diastolic filling velocity (wave E); peak of late diastolic filling velocity (wave A); ratio between the waves E and A (E/A); The study was complemented by tissue Doppler evaluation of the systolic displacement (S'). Results The groups had no difference in body weight over the course of 20 weeks of treatment, however the CHO group had significant cardiac changes. Conclusion The consumption of a high carbohydrate diet led to concentric cardiac remodeling associated with systolic dysfunction. Cardiac structure Echocardiogram 20 weeksVariables Groups p Control CHOBW (g) 480,0 ± 50,0 491,3 ± 66,8 0,393LVDD (mm) 7,11 ± 0,60 6,79 ± 0,56 0,020LVSD (mm) 3,01 ± 0,38 3,22 ± 0,53 0,050PWTd(mm) 1,54 ± 0,11 1,95 ± 0,12 <0,001PWTs (mm) 3,20 ± 0,32 3,24 ± 0,25 0,494SWTd(mm) 1,60 ± 0,11 2,25 ± 0,32 <0,001SWTs(mm) 3,60 ± 0,27 3,67 ± 0,31 0,293AD (mm) 3,73 ± 0,23 3,95 ± 0,20 <0,001LA (mm) 4,73 ± 0,21 6,10 ± 0,39 <0,001LA/AD 1,27 ± 0,09 1,54 ± 0,10 <0,001LVDD/BW 14,90 ± 1,39 13,99 ± 1,65 0,009LA/BW 9,95 ± 1,06 12,59 ± 1,57 <0,001LVM 0,75 ± 0,13 1,06 ± 0,20 <0,001LVMI 1,57 ± 0,24 2,19 ± 0,45 <0,001RTLV 0,44 ± 0,04 0,58 ± 0,06 <0,001Cardiac Function Echocardiogram 20 weeksVariables GroupsControl CHO pCardiac Output 89,392 ± 24,927 79,439 ± 23,963 0,070Cardiac Index 186,649 ± 51,512 162,655 ± 47,097 0,030%short.endo 57,638 ± 3,741 52,636 ± 5,828 <0,001%short.meso 26,069 ± 3,388 24,846 ± 4,007 0,144E mitral 77,228 ± 10,673 80,978 ± 9,803 0,105A mitral 48,648 ± 12,012 50,855 ± 15,518 0,478E/A 1,629 ± 0,274 1,717 ± 0,488 0,326Ejection Fraction 0,922 ± 0,020 0,889 ± 0,041 <0,001S lateral 5,633 ± 0,551 5,173 ± 0,459 <0,001S septal 5,603 ± 0,390 5,110 ± 0,458 <0,001S average 5,618 ± 0,386 5,141 ± 0,374 <0,001