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Lactobacillus paracasei N1115 can Alter Lipid Metabolismin of High‐fat Diet Fed SD Rats
Author(s) -
Pu Fangfang,
Guo Yue,
Wang Shijie,
Zhu Hong,
Shen Xi,
Wu Zixi,
Li Ming,
He Fang
Publication year - 2017
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.31.1_supplement.965.4
Subject(s) - adiponectin , leptin , endocrinology , medicine , lactobacillus paracasei , nonalcoholic fatty liver disease , dyslipidemia , lipid metabolism , obesity , blood lipids , fatty liver , biology , cholesterol , insulin resistance , lactobacillus , food science , disease , fermentation
Background and Objective High‐energy or isocaloric fat‐rich diet have been well known to associate with metabolic diseases such as obesity, dyslipidemia and nonalcoholic fatty liver disease. Fat deposition in the liver has been recognized as one major cause to promote metabolic diseases. Accumulative evidences indicated that the gut microbes might be one of the critical factors to connect high‐fat diet and metabolic diseases positively or negatively. Especially, probiotics, particularly certain lactobacilli could exert a protective effect. In the present study, we attempted to clarify the potential effects of a selected probiotics strain, Lactobacillus paracasei N1115 (N1115) on lipid metabolism in rats undergoing high‐fat diet. Methods A total of 32 male sprague‐dawley rats were randomly assigned into four groups and maintained for 18 weeks: control goup (standard chow), model group (high‐fat diet), low N1115 group (high‐fat diet + heat‐killed N1115 with 1.5×10 9 CFU/mL) and high dose N1115 group (high‐fat diet + heat‐killed N1115 with 7.5×10 9 CFU/mL). Weight and body length were measured weekly. Blood of the tested rats were collected in 0, 5, 10, 18 weeks. Results 18‐week high‐fat feeding induced significantly higher hepatic lipid accumulation, and apparently lowered adiponectin production, although no significant difference were found in weight, serum glucose, insulin, leptin, cholesterol and triglycerides level compared with control. Compared to the model group, N1115 significantly lowered hepatic lipids and increased serum adiponectin, leptin and interleukin (IL)‐6 level. Furthermore, N115 has also significantly lowered expression of the hepatic peroxisome proliferator‐activated receptor (PPAR) α compared with those in the model group too. Liver histopathological analysis also showed that N1115 ameliorated fat accumulation in the liver. Conclusions These results suggest that heat‐killed L. paracasei N1115 may effectively suprrese high‐fat diet induced fat accumulation in liver, thereby producing a beneficial effects when long‐term consumption of high‐fat diet.