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B cell cytokine secretion and antibody production are impaired upon BCR/TLR9 stimulation in obese subjects
Author(s) -
Kosaraju Rasagna,
Guesdon William,
Shaikh Saame Raza
Publication year - 2017
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.31.1_supplement.964.6
Subject(s) - stimulation , endocrinology , medicine , b cell , tlr9 , cytotoxic t cell , cytokine , secretion , immunology , obesity , antibody , biology , gene expression , biochemistry , dna methylation , in vitro , gene
Obesity is hypothesized to drive an impairment in humoral immunity. However, it is unclear how obesity directly targets B cell responses in humans. This study investigated how obese subjects, relative to lean controls, responded to anti‐B cell receptor (BCR) and toll‐like receptor (TLR) 9 stimulation. Obese individuals with a BMI of >30 had a significant increase in the percentage of B cells in circulation compared to their lean counterparts whereas the percentage of monocytes, helper T cells, and cytotoxic T cells remained unchanged. B cell IL‐6 secretion was lowered upon anti‐BCR/TLR9 stimulation in the obese compared to lean controls. Furthermore, a positive correlation was observed between BMI and IgM, but not IgG, production upon anti‐BCR/TLR9 stimulation. These results demonstrate that B cell function is impaired in obese individuals, which could contribute toward diminished responses to infection and vaccination in obesity. Support or Funding Information Research was supported by NIH R01AT008375