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Cranberry Beverage Consumption Reduces Antibiotic Use for Clinical Urinary Tract Infection in Women with a Recent History of Urinary Tract Infection
Author(s) -
Nieman Kristin M,
Dicklin Mary R,
Schild Arianne L,
Kaspar Kerrie L,
Khoo Christina,
Derrig Linda H,
Gupta Kalpana,
Maki Kevin C
Publication year - 2017
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.31.1_supplement.964.26
Subject(s) - medicine , antibiotics , urinary system , incidence (geometry) , placebo , confidence interval , clinical trial , cranberry juice , randomized controlled trial , rate ratio , microbiology and biotechnology , physics , alternative medicine , optics , pathology , biology
Urinary tract infection (UTI) is one of the most commonly diagnosed types of bacterial infection, and is often treated with antibiotic therapy. Preventive approaches are needed to minimize unnecessary use of antibiotic therapy, which can contribute to the development of antibiotic resistant pathogens. The effect of the consumption of a daily cranberry beverage (240 mL/d; n = 185) compared to a placebo beverage (n = 188) on episodes of clinical UTI was investigated in a 24‐week, randomized, double‐blind, placebo‐controlled, multicenter clinical trial in women with a history of a recent UTI ( Am J Clin Nutr 2016;103:1434–42; NCT01776021). The aim of this post‐hoc analysis was to evaluate the effect of consuming the cranberry beverage on the incidence of antibiotic use for treatment of three categories of clinical UTI: investigator‐diagnosed, probable UTI (subject was not examined by the investigator but a non‐study healthcare provider prescribed an antibiotic), and possible UTI (self‐administered antibiotic therapy). Investigator‐diagnosed episodes of clinical UTI were significantly reduced in the cranberry beverage group, relative to placebo (39 vs. 66; incidence rate ratio [IRR]: 0.63; 95% confidence interval [CI]: 0.42, 0.93; P = 0.021). There was a trend for reduced investigator‐diagnosed plus probable episodes of UTI in the cranberry group (47 vs. 71; IRR: 0.70; 95% CI: 0.48, 1.01; P = 0.056). Investigator‐diagnosed plus probable and possible episodes of UTI were significantly reduced in the cranberry group (47 vs. 73; IRR: 0.68; 95% CI: 0.47, 0.98; P = 0.038). The results of this post‐hoc analysis indicate that daily consumption of a cranberry beverage reduced the incidence of antibiotic treated clinical UTI in women with a recent history of UTI. Support or Funding Information Funded by Ocean Spray Cranberries, Lakeville‐Middleboro, MA