Premium
Effect of Vitamin D3 Supplementation on Blood Pressure in Hispanics with Type 2 Diabetes
Author(s) -
Zarini Gustavo G.,
Exebio Joel,
Vaccaro Joan A.,
McLean Michael,
Ajabshir Sahar,
Huffman Fatma G.
Publication year - 2017
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.31.1_supplement.961.12
Subject(s) - medicine , blood pressure , vitamin d and neurology , type 2 diabetes , analysis of variance , vitamin , diabetes mellitus , repeated measures design , endocrinology , statistics , mathematics
Significance Serum vitamin D deficiency/insufficiency and elevated blood pressure are important health concerns especially among Hispanics. Additionally, Hispanics are at high risk for type 2 diabetes. Available evidence from observational studies indicated that low 25‐hydroxy vitamin D [25(OH)D] levels are associated with elevated blood pressure. However, studies have found contradictory relationship between vitamin D3 supplementation and blood pressure. Objective To evaluate the effect of vitamin D3 supplementation at 6000 IU/day on systolic and diastolic blood pressure levels in Hispanics with type 2 diabetes and hypovitaminosis D [25(OH)D < 30 ng/mL]. Methods Participants (n=22) were recruited from two clinics in Miami‐Dade County, FL, US (Borinquen Health Care Center and Clinical Care Medical Center). Twenty milliliters of venous blood (at least 8 hours fasting) was collected from each participant by a certified phlebotomist using standard laboratory methods. Serum 25(OH)D levels were determined using a commercial ELISA kit from Immunodiagnostic Systems Limited (Scottsdale, AZ, USA). Systolic and diastolic blood pressure were measured twice in a sitting position using a calibrated arm‐cuff automatic blood pressure monitor. Average of the two readings was used for analysis. Participants were given 6000 IU/day of vitamin D3 supplementation for 6 months. All data analyses were conducted on an “intent to treat” basis. Statistical analysis included descriptive statistics and one‐way repeated‐measures ANOVA. Results Adjusted repeated measures ANOVA determined that mean systolic blood pressure levels differed statistically significantly between time points (F(1.611) = 4.883), p<0.015). Post‐hoc test using Bonferroni correction indicated that vitamin D3 supplementation at 6000 IU/day significantly reduced mean systolic blood pressure levels from baseline (146.6 ± 18.4) to 3 months (137.0 ± 16.2, p=0.026) and statistically greater reduction was observed at 6 months (133.6 ± 17.8, p=0.014). Diastolic blood pressure levels did not change significantly over time. Conclusion Vitamin D3 supplementation at 6000 IU/day significantly decreased systolic blood pressure levels in Hispanics with type 2 diabetes. Improving blood pressure levels with supplementation of vitamin D3 may prevent/delay future complications associated with cardiovascular disease and disease progression of type 2 diabetes. Larger randomized controlled trials are needed to confirm these results in this and other racial/ethnic groups.