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Molecular Mechanisms of Retinal Circuit Assembly
Author(s) -
Kerschensteiner Daniel
Publication year - 2017
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.31.1_supplement.96.2
Subject(s) - retina , neuroscience , retinal , synapse , neuronal circuits , neuron , biology , function (biology) , cell type , microbiology and biotechnology , cell , biochemistry
The mammalian retina comprises approximately neuronal cell types, which assemble into a variety of circuits that mediate diverse visual functions. I will discuss ongoing studies in my lab, which identified leucine‐rich repeat (LRR) proteins that guide the assembly of specific circuits in the outer and inner retina. In addition to elucidating the contributions of these LRR proteins to morphological maturation and synapse development of specific neuron types, we analyze their impact on circuit function and visually guided behaviors. Support or Funding Information NIH (EY023341, EY026978, EY027411)