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Association Between Maternal Dietary Inflammatory Index Score During Pregnancy and Child Wheeze at Age Three Among Children from Shelby Co, TN
Author(s) -
Kowalski Alysse,
Carroll Kecia,
Shivappa Nitin,
Roy Aditi,
Kocak Mehmet,
Steck Susan,
Hebért James,
Tylavsky Fran,
Hartman Terry
Publication year - 2017
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.31.1_supplement.959.16
Subject(s) - wheeze , medicine , pregnancy , odds ratio , cohort , confidence interval , logistic regression , pediatrics , cohort study , obstetrics , demography , asthma , genetics , sociology , biology
Objective This analysis examined the association between a dietary inflammatory index (DII) computed from maternal dietary and supplement intake in the second trimester of pregnancy and current child wheeze at age 3 years in a cohort of mother‐child dyads. Methods The Conditions Affecting Neurocognitive Development in Early Childhood (CANDLE) study is a prospective cohort study of singleton pregnancies that enrolled 1503 pregnant mothers in Shelby County TN; 798 mother‐child dyads were included in this analysis. Loss to follow‐up by 3‐year visit was the primary reason for exclusion. The exposure was the DII, an a priori dietary pattern that classifies diets on a continuum from maximally anti‐inflammatory (low scores) to maximally pro‐inflammatory (high scores). The DII was computed from second trimester maternal diet and supplement intake data assessed using the 2005 Block food frequency questionnaire. The DII was calculated in two ways: without energy adjustment (DII total) and with energy adjustment via the density method (E‐DII), both as continuous variables. The outcome of interest was current wheeze at age 3, defined by parental report of history of wheeze and an episode in the previous 12 months. Multivariable logistic regression was used to estimate odds ratios (OR) with 95% confidence intervals (95% CI) between maternal DII during pregnancy and child current wheeze at age three after adjustment for maternal education and race. Results Prevalence of current child wheeze was 20.9%. The DII total ranged from −5.22 to 3.67 and was normally distributed with mean −2.10 (SD ±1.5). The DII density ranged from −5.25 to 3.25 and was normally distributed with mean −2.02 (SD ±1.64). Preliminary results suggested the DII was not associated with current child wheeze (DII total aOR: 0.98; 95% CI: 0.88, 1.10 and E‐DII aOR: 0.99; 95% CI: 0.88, 1.11). Conclusion Preliminary findings suggest maternal dietary and supplement intake during second trimester, as characterized by the DII, is not associated with current child wheeze at age three.