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Attenuation of Mitochondrial Dysfunction During Hepatic Steatosis by Avocado Oil Supplementation
Author(s) -
GarciaBerumen Claudia isabel,
OrtizAvila Omar,
MárquezRamírez Cristian Adrián,
CalderónCortés Elizabeth,
MontoyaPérez Rocío,
RodriguezOrozco Alain R.,
Molina Alfredo Saavedra,
CortésRojo Christian
Publication year - 2017
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.31.1_supplement.944.16
Subject(s) - steatosis , nonalcoholic fatty liver disease , fatty liver , cirrhosis , mitochondrion , oxidative stress , medicine , insulin resistance , diabetes mellitus , fibrosis , steatohepatitis , type 2 diabetes , endocrinology , disease , biology , biochemistry
Nonalcoholic Fatty Liver Disease (NFLD) is a clinical syndrome characterized by excessive fat accumulation in the liver and hepatic cellular degeneration even in the absence of alcohol consumption. Mechanisms of alcoholic liver disease have been extensively studied; however, the events that cause progression to hepatitis and fibrosis/cirrhosis are still undefined. It has been recently recognized that mitochondrial dysfunction and mitochondrial oxidant production may play a critical role in the development of NAFLD and progression to nonalcoholic steatohepatitis (NASH). We have recently reported that avocado oil intake has protective effects against mitochondrial dysfunction during diabetes by increasing the resistance of the respiratory chain (RC) to oxidative stress, decreasing ROS production and enhancing glutathione availability Therefore, we aimed to test whether avocado oil protects from the alterations elicited by diabetes on RC function in liver mitochondria from rats with NAFLD. Mitochondria from rats with NAFLD exhibited decreased respiration, impaired activity of complex III and diminished reduction of cytochromes b and c+c 1 . All these effects were corrected when avocado oil was supplemented after the establishment of NAFLD but not before the induction of the disease. These data suggest that avocado oil could be beneficial to decrease NAFLD progression by improving mitochondrial function. Support or Funding Information Acknowledgments: this work was supported by a Coordinación de la Investigación Científica‐UMSNH grant (CCR).