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Improvement of diabetic cardiomyopathy by Eryngium carlinae
Author(s) -
GarcíaCerrillo Diana,
NoriegaCisneros Ruth,
SalgadoGarciglia Rafael,
ManzoAvalos Salvador,
ClementeGuerrero Mónica,
MontoyaPérez Rocío,
SaavedraMolina Alfredo
Publication year - 2017
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.31.1_supplement.944.15
Subject(s) - diabetic cardiomyopathy , tbars , diabetes mellitus , streptozotocin , oxidative stress , thiobarbituric acid , medicine , antioxidant , reactive oxygen species , endocrinology , chemistry , pharmacology , lipid peroxidation , cardiomyopathy , biochemistry , heart failure
Diabetes mellitus (DM) is a metabolic disease that has increased significantly in recent decades. DM and its complications are powerful risk factors for cardiovascular diseases. Diabetic heart damage is closely related to mitochondrial dysfunction and an increase in the generation of reactive oxygen species. The external supply of antioxidants can counteract the effect of such species on the body, and prevent the onset of many underlying diseases. Natural sources of antioxidants may be safer to use with regard to synthetic antioxidants, due to lower toxicity and side effects. Eryngium carlinae (EC) is a plant used in traditional Mexican medicine, whose hexanic extract has been shown to possess in vitro antioxidant capacity. The serum and heart mitochondria of male Wistar rats were analyzed. Previously experimental diabetes was induced with streptozotocin (STZ) and they were treated with hexanic extract of EC for seven weeks (30 mg/kg body weight). Cholesterol, triacylglycerides and glucose and lipoperoxidation levels were determined in serum. In addition, in the left ventricle heart mitochondria, oxidative and nitrosative stress levels were determined through the quantification of parameters such as thiobarbituric acid reactive substances (TBARS) and nitric oxide (NO) levels, and tissue histological analysis was performed. The results of the biochemical parameters of glucose and triacylglycerides show a significant decrease of the diabetic group treated with extract with respect to the diabetic group without treatment. Similarly, there was a significant decrease in lipoperoxidation levels in the diabetic group treated with extract compared to the untreated diabetic group. Histological observation shows signs of hypertrophy of the left ventricle of diabetic rats which appears to be diminished by treatment with EC extract. In conclusion, EC hexanic extract possesses antioxidant activity in vivo in the groups in addition to possessing the ability to lower glucose and triglyceride levels in diabetic rats, which may prevent or delay the development of diabetic cardiomyopathy. Support or Funding Information Acknowledgments: Special thank for the grants of CIC‐UMSNH: 2.10 to RSG; 2.16 to ASM, and 2.37 to SMA.