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The Effect of Alcohol Consumption on Adipokine Secretion
Author(s) -
DeGroat Ashley R.,
Peterson Jonathan M.
Publication year - 2017
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.31.1_supplement.887.12
Subject(s) - adipokine , adiponectin , endocrinology , medicine , steatosis , adipose tissue , insulin resistance , chemistry , alcoholic fatty liver , fatty liver , insulin , disease
The goal of this project was to establish the effect of alcohol consumption on adipose tissue‐derived secreted factors; adiponectin and C1q TNF Related Proteins 1–3 (CTRP1‐3). Alcoholic Fatty Liver Disease (AFLD) is caused by excessive alcohol consumption and is a leading cause of liver related mortalities, with currently no treatments available. Both adiponectin and CTRP3 have been shown to reduce excessive hepatic lipid accumulation, and CTRP1 and CTRP2 have both been linked to beneficial effects on lipid metabolism. Further, adiponectin has been shown to decrease with alcohol consumption. Therefore, we propose that excessive alcohol consumption will reduce circulating levels of not only adiponectin but other adipokines, specifically CTRP1‐3. The deregulation of adipokine secretion can contribute to the development of hepatic insulin resistance, inflammation, and steatosis. To test the effects of alcohol consumption on adipokines, 12‐week old female mice were fed a Lieber‐Decarli alcohol diet (5% ETOH by volume) for either 10‐days ending with a binge (chronic plus binge model) or for 6‐weeks with no binge added (chronic model). Serum was collected from the mice and CTRP1, CTRP2, CTRP3, and adiponectin levels were examined by immunoblot analysis. RESULTS In response to the chronic plus binge model adiponectin and CTRP1 levels decreased and no change in CTRP2 or CTRP3 levels were observed. After 6‐weeks of ETOH feeding there were still no differences in circulating CTRP2 or CTRP3 levels, however, adiponectin and CTRP1 levels were both increased. These results indicate that long‐term alcohol consumption effects adipokine secretion in a specific manner. Further research will be needed to explore the physiological relevance of these findings, specifically, to determine if these changes are beneficial compensations to combat the negative effects of excessive alcohol consumption. Lastly, even though CTRP2 and CTRP3 levels were unaffected by chronic alcohol consumption, elevated CTRP2 and CTRP3 may still be beneficial in combating the progression of AFLD. Support or Funding Information This research was supported in part National Institute On Alcohol Abuse And Alcoholism of the National Institutes of Health under Award Number R03AA023612 and East Tennessee State University Research Development Committee (E82262).