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Modeling human development using insights from organoids and embryos
Author(s) -
Spence Jason
Publication year - 2017
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.31.1_supplement.85.2
Subject(s) - organoid , induced pluripotent stem cell , biology , model system , function (biology) , microbiology and biotechnology , computational biology , neuroscience , embryonic stem cell , computer science , genetics , gene
Recent breakthroughs have allowed the development of 3‐dimensional (3D) organ‐like “organoid” models, derived from human pluripotent stem cells (hPSC), for many organ systems. These models are physiologically complex and recreate several aspects of the complex organ structure and function seen in vivo. We will discuss ongoing work to develop and implement hPSC derived lung and intestinal organoid model systems in order to gain insights into human organ development and maturation.