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Effect of Exercise Training on Neurovascular Control During Mental Stress in Patients with Acute Coronary Syndrome
Author(s) -
FerreiraSantos Larissa,
Martinez Daniel Godoy,
Nicolau José Carlos,
Moreira Humberto Graner,
Alves Maria Janieire NN,
Trombetta Ivani Credidio,
Negrão Carlos Eduardo,
Rondon Maria Urbana PB
Publication year - 2017
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.31.1_supplement.847.9
Subject(s) - medicine , neurovascular bundle , cardiology , forearm , brachial artery , microneurography , stroop effect , mental stress , anesthesia , physical therapy , heart rate , blood pressure , surgery , baroreflex , cognition , psychiatry
Patients with myocardial infarction present abnormal neurovascular control at rest and during physiological conditions. On the other hand, exercise training (ET) restores the autonomic control in these patients. However, the effect of ET on neurovascular control during a defense reaction of mental stress in patients with acute coronary syndrome (ACS) remains unknown. We tested the hypothesis that long‐term ET would decrease muscle sympathetic nerve activity (MSNA) and would increase the skeletal muscle vasodilatation during mental stress in ACS patients. Thirty‐four patients with ACS with preserved ventricular function were allocated in two groups: 1) ET (ACS‐ET, n=17) and 2) Untrained (ACS‐U, n=17). MSNA was recorded directly from the peroneal nerve by microneurography and forearm blood flow was measured by venous occlusion plethysmography. The six‐month ET program was supervised and consisted of three 60‐min exercise sessions/week. Mental stress was elicited by a mental challenge of Stroop Color Word Test during 3 minutes. MSNA significantly decreased during mental stress in the ACS‐ET group ( P =0.002), but not in the ACS‐U group. In addition, in the post‐intervention period, the levels of MSNA during mental stress were significantly lower in the ACS‐ET group in compared with ACS‐U group ( P =0.04). ET did not significantly change the forearm vascular conductance during mental stress. However, in the post‐intervention period, the forearm vascular conductance response was significantly higher in the ACS‐ET group compared with ACS‐U group ( P <0.001). In conclusion, ET improves neurovascular control during a defense reaction of mental stress in patients with ACS. Therefore, these results emphasize the importance of prescribing ET in the treatment of these patients. Support or Funding Information Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP #2010/50048‐1); Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq#475911/2013‐0, #309821/2014‐2 and #308068/2011‐4) and Coordenação de Aperfeiçoamento de Pessoal de Nível Superior‐ CAPES