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Taurine Supplementation Improves Arterial Pressure Control Function after Cardiac Ischemia/Reperfusion via Systemic Inhibition of the Renin‐Angiotensin System in Adult Female Rats Perinatally Depleted of Taurine and Supplemented with High Sugar
Author(s) -
Roysommuti Sanya,
Kulthinee Supaporn,
Wyss James Michael
Publication year - 2017
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.31.1_supplement.846.5
Subject(s) - taurine , medicine , endocrinology , angiotensin ii , blood pressure , renin–angiotensin system , creatinine , mean arterial pressure , chemistry , hemodynamics , cardiac function curve , heart rate , heart failure , amino acid , biochemistry
Perinatal taurine depletion followed by a high sugar diet exacerbates cardiac injury and arterial pressure dysregulation after ischemia/reperfusion (IR), and this effect is blunted by taurine supplementation or inhibition of renin‐angiotensin system. This study tests the hypothesis that taurine supplementation improves arterial pressure control in this model via systemic inhibition of renin‐angiotensin system overactivity. Female Sprague‐Dawley rats were fed normal rat chow with tap water alone (control, C) or tap water containing 3% beta‐alanine (taurine depletion, TD) from conception to weaning. Female offspring were fed the normal rat chow and drank 5% glucose in tap water (CG and TDG) or tap water alone (CW and TDW) throughout the study. One week before surgery, half of rats in each treatment were supplemented with 3% taurine in tap water (CW+T, CG+T, TDW+T, and TDG+T). At 7–8 weeks of age, blood chemistry and hemodynamic parameters were studied in conscious and anesthetized rats after cardiac IR induction and in untreated Sham control rats. Body and heart weights, plasma electrolytes, plasma creatinine, and blood urea nitrogen were not significantly different among the nine groups. However, plasma angiotensin II concentrations were markedly and significantly elevated in TDG compared to all other groups (Sham, 33.9 ± 4.4 pg/ml; CW, 20.2 ± 2.3 pg/ml; CW+T, 24.4 ± 4.3 pg/ml, CG, 20.8 ± 2.9 pg/ml; CG+T, 20.2 ± 2.3 pg/ml; TDW, 22.6 ± 2.5 pg/ml; TDW+T, 15.1 ± 1.0 pg/ml; TDG, 61.1 ± 7.6 pg/ml (p < 0.05 to all other groups); TDG+T, 32.8 ± 4.7 pg/ml). After cardiac IR, mean arterial pressure significantly increased in all IR groups, compared to their corresponding values before IR. Further, in the TDG compared to all other groups, baroreflex sensitivity was markedly and significantly depressed and sympathetic nerve activity was significantly increased. Power spectral analysis of renal nerve activity indicated a significant increase in renal renin release only in the TDG compared to all other groups, though renal firing frequency increased in CG, TDW, TDW+T, TDG, and TDG+T groups. The adverse effects of cardiac IR on arterial pressure control, renin release, and plasma angiotensin II were improved by short‐term taurine supplementation. The present study demonstrates that in adult female rats perinatally depleted of taurine followed by a high sugar diet, taurine supplementation improves the adverse effects of cardiac IR on arterial pressure control via inhibition of systemic renin‐angiotensin system overactivity. Support or Funding Information This work was supported by Khon Kaen University, Khon Kaen, Thailand.