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Effects of Aerobic Capacity on Arterial Stiffness in Individuals with Multiple Sclerosis
Author(s) -
Grigoriadis Georgios,
Rosenberg Alexander J.,
Wee Sang Ouk,
Schroeder Elizabeth C.,
Hilgenkamp Thessa I.M.,
Griffith Garett,
Baynard Tracy
Publication year - 2017
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.31.1_supplement.840.30
Subject(s) - arterial stiffness , medicine , cardiology , aerobic capacity , aerobic exercise , treadmill , compliance (psychology) , vo2 max , blood pressure , heart rate , psychology , social psychology
Individuals with Multiple Sclerosis (MS) exhibit a greater risk of cardiovascular disease than individuals without MS, and increased arterial stiffness is one possible risk factor. Higher aerobic capacity has been associated with lower arterial stiffness in healthy individuals and helps explain lower risk profiles. Individuals with MS in general have low aerobic capacities and the effect of MS may abolish expected relationships between fitness and arterial stiffness. PURPOSE To determine the relationship between peak oxygen consumption (VO 2peak ) and carotid arterial stiffness in individuals with MS. METHODS Thirteen individuals with MS (43 ± 9 yrs; 25.0 ± 3.7 kg/m 2 ) underwent an individualized incremental treadmill test to volitional exhaustion with measures of oxygen uptake. Carotid arterial stiffness was measured by ultrasonography prior to the treadmill test, and echo‐tracking software was used to calculate the β‐stiffness index, pressure‐strain elasticity modulus (Ep) and arterial compliance (AC). Bivariate correlations were implemented to examine the linear relationship between VO 2peak and carotid arterial stiffness. Partial correlations were performed to control for body weight. RESULTS Negative correlations were observed between absolute VO 2peak and β‐stiffness index, (p<0.05) and Ep (p<0.05), whereas a positive correlation was found with AC (p<0.05). However, the significance between VO 2peak and carotid stiffness variables was eliminated when controlling for body weight. CONCLUSION The findings suggest that aerobic capacity is negatively associated with carotid arterial stiffness and positively associated with arterial compliance, while body weight influences these relationships in an expected manner. Thus, aerobic training and/or weight loss might be an effective treatment to decrease arterial stiffness and consequently risk of cardiovascular disease in a population with MS.Arterial Stiffness Variables Absolute VO 2peak Bivariate Correlation Absolute VO 2peak Partial Correlationβ‐stiffness index −0.604 * −0.421 Ep (kPa) −0.682 * −0.529 AC (mm 22 /kPa) 0.672 * 0.508* Significant correlation: p<0.05