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The Effect of an Antioxidant Cocktail on Indices of Cerebral and Peripheral Vascular Function in Healthy College‐Age Men
Author(s) -
Curtis Bryon M,
Patik Jordan C,
Vranish Jennifer R,
Kaur Jasdeep,
Young Benjamin E,
Fadel Paul J,
Brothers R. Matthew
Publication year - 2017
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.31.1_supplement.840.18
Subject(s) - medicine , arterial stiffness , brachial artery , pulse wave velocity , blood pressure , oxidative stress , vitamin e , cardiology , anesthesia , antioxidant , endocrinology , chemistry , biochemistry
The detrimental effect of systemic oxidative stress on vascular function has been well documented, yet there is disagreement in the literature regarding the capacity of oral antioxidants to mitigate these effects. However, the majority of these studies have assessed the role of oxidative stress using a single antioxidant treatment (i.e. Vitamin C only). Recently it was reported that an oral antioxidant cocktail (AOX) consisting of vitamin C (2g), vitamin E (150IU), and coenzyme Q10 (100mg) significantly reduced oxidative stress, muscle sympathetic nerve activity, and blood pressure in relatively young and healthy adults. Whether this AOX also improves indices of vascular function remains unknown. Thus, the purpose of this current investigation was to test the hypothesis that an AOX would augment indices of cerebral and peripheral vascular function. 7 relatively young healthy men (age: 24 ± 5 yr) participated in this protocol. All measures were obtained in the morning following an overnight fast during 2 separate visits to the laboratory separated by ~ 1 week, with AOX or a placebo (three sugar pills) being administered in random order. Cerebral vascular function was assessed as the increase in cerebral vascular conductance (CVCI: middle cerebral artery blood velocity (MCAV mean )/mean arterial pressure (MAP)) before and during rebreathing‐induced hypercapnia. Peripheral vascular function was assessed as flow‐mediated dilation (FMD) of the brachial artery following a 5 min period of cuff occlusion. Arterial stiffness was also assessed via augmentation index (AIX@75) and pulse‐wave velocity (PWV), using brachial pulse wave analysis and applanation tonometry, respectively. The increase in CVCI during the highest common elevation in end‐tidal carbon dioxide achieved between the two days was similar (placebo: 130 ± 10% of baseline, AOX: 128 ± 3% of baseline; P= 0.77). Likewise, FMD (placebo: 5.3 ± 2.2% of baseline, AOX: 5.5 ± 1.6% of baseline; P= 0.55), AIX@75 (placebo: −8.8 ± 14.2%, AOX: −5.7 ± 8.3%; P= 0.33), and PWV (placebo: 6.3 ± 0.9 m/s, AOX: 6.1 ± 0.9 m/s; P= 0.55) were not different between AOX and placebo study visits. Contrary to our hypothesis, these preliminary findings suggest that AOX does not affect indices of cerebral or peripheral vascular function in relatively young and healthy men.