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The Effect of a High‐Fat Meal on Vascular Stiffness in Young Healthy Males
Author(s) -
Tucker Wesley,
Patik Jordan,
Curtis Bryon,
Park Suwon,
Nelson Michael,
Brothers R. Matthew
Publication year - 2017
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.31.1_supplement.840.16
Subject(s) - arterial stiffness , medicine , pulse wave velocity , blood pressure , cardiology , brachial artery , postprandial , endothelial dysfunction , heart rate , pulse pressure , insulin
Consumption of a high‐fat meal (HFM) has been implicated in the pathogenesis of cardiovascular disease (CVD). While the exact mechanism remains unclear, postprandial lipemia, low‐grade inflammation, and endothelial dysfunction are contributing factors. Whether impairments in other indices of vascular function, such as central aortic pressures and arterial stiffness, also occurs following a HFM remains unknown and was the focus of this investigation. Six (n=6) healthy young males (27±5 years) were randomized to the following conditions, performed on separate days following an overnight fast: a) HFM challenge (928 kcal, ~50% fat) or, b) time control (fasting). Measures were assessed at baseline, 2h‐, and 4h post‐HFM or at a similar time point on the fasting day. Peripheral blood pressure, central aortic blood pressure and augmentation indices (augmentation pressure [AP] and augmentation index normalized for heart rate 75 bpm [Aix@75]) were non‐invasively assessed by brachial pulse wave analysis (SphygmoCor System, ATCor Medical, Australia). Arterial stiffness was assessed by carotid‐femoral pulse wave velocity (cf‐PWV) using applanation tonometry (SphygmoCor System, ATCor Medical, Australia). Endothelial function was assessed as flow‐mediated dilation (FMD) of the brachial artery using high‐resolution 2D and Doppler ultrasound (GE Logiq P5, GE Healthcare, UK) and normalized for shear rate area under the curve (AUC). Blood triglycerides (TG) were assessed at baseline and 2h post‐meal for each condition. Two‐way repeated measures ANOVA was used to detect time, condition, or time × condition interaction effects. Consistent with previous reports, consumption of the HFM significantly elevated blood TG relative to the time control day (HFM: 101±38 to 169±77 mg/dl, Fasting day: 107±32 to 92±31 mg/dl, P=0.007). Likewise, endothelial function also tended to be reduced 2h following the HFM (Baseline: 0.17±0.13, 2h: 0.12±0.07 % FMD/shear AUC) compared to the fasting day which tended to increase at 2h (Baseline: 0.12±0.05, 2h: 0.15±0.10 % FMD/shear AUC) (p=0.09). In contrast to our hypothesis, the HFM had no effect on central systolic BP (p=0.43), central diastolic BP (p=0.81), AP (p=0.20), Aix @75 (p=0.21) and cf‐PWV (p=0.20). These preliminary data suggest that central aortic blood pressures and arterial stiffness do not change acutely following a HFM in young healthy males.