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COMBINED EXERCISE TRAINING (AEROBIC PLUS RESISTANCE) PROMOTES ADDITIONAL CARDIOVASCULAR BENEFITS IN RELATION TO AEROBIC OR RESISTANCE ALONE IN EXPERIMENTAL MODEL OF MENOPAUSE
Author(s) -
Sanches Iris Callado,
Santos Costa Gabrielly Minguta,
Freitas Sarah Cristina,
Bernardes Nathalia,
Doro Marcio,
Irigoyen MariaCláudia,
De Angelis Kátia
Publication year - 2017
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.31.1_supplement.839.9
Subject(s) - aerobic exercise , medicine , baroreflex , menopause , blood pressure , heart rate , mean arterial pressure , rowing , ovariectomized rat , resistance training , endocrinology , sodium nitroprusside , cardiology , anesthesia , estrogen , nitric oxide , archaeology , history
The cardiovascular benefits of exercise training (ET) after menopause are mainly due to the aerobic training, getting to doubt whether the association of aerobic with resistance exercise could bring different effects. Objectives To compare the effects of aerobic, resistance and combined (aerobic + resistance) exercise training on hemodynamic parameters and baroreflex sensitivity in an experimental model of menopause. Methods For this, 35 female Wistar rats (200–220g) were divided into (n=7 each group): 1 sedentary control group (C); and 4 ovariectomized groups (bilateral removal of ovaries): sedentary (SO), underwent to aerobic (AET), resistance (RET) and to combined ET (CET). After 8 weeks of ET, the animals were cannulated in the carotid artery for direct recording of arterial pressure (AP) (CODAS, 2kHz). Increasing doses of phenylephrine and sodium nitroprusside were used to test the baroreflex sensitivity (BS). Results The ovarian hormone deprivation induced an increase in mean AP (MAP) in the SO group (119.8±2.5 vs. 114.5±1.5 mmHg in C) associated with reduced BS for both tachycardic responses (TR) (2.67±0.55 vs. 4.29±0.41 bpm/mmHg in C) and for bradycardic responses (BR) (−0.61±0.36 vs. −1.17±0.16 bpm/mmHg in C). All trained animals presented a normalization of MAP (AET: 111.7±1.5, RET: 108.9±2.4, CET: 107.6±3.0 mmHg vs. SO), which was associated with reduction of diastolic AP (vs. SO). The group underwent to combined ET presented a reduction in systolic AP compared with the other groups (CET: 115.7±2.3 vs. C: 131.6±2.1; SO: 135.5±3.8, AET: 130.9±1.8; RET: 131.9±2.6 mmHg). The trained groups showed normalization of baroreflex sensitivity for BR (AET: −0.97±0.16; RET: −1.29±0.20; CET: −1.34±0.04 vs. SO), and only resistance ET was not able to normalize RT (AET: 4.12±21; RET: 3.59±0.62; CET: 3.95±0.38 bpm/mmHg vs. SO). All trained groups showed resting bradycardia (C: 368.4±5.5; SO: 382.9±8.9; AET: 335.5±6.9; RET: 353.0±8.2; CET: 345.7±8.1 vs. SO: 382.9 ± 8.9 bpm). Conclusions The 3 modalities of ET were effective in cardiovascular improvement after ovarian hormone deprivation. However, the combined ET promoted additional benefits in relation to aerobic ET (reduction in SAP) and resistance ET (improved baroreflex sensitivity ‐ TR) isolated.