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Relationships between Functional Capacity and Hemodynamic Characteristics in Patients with Peripheral Arterial Disease
Author(s) -
Fu TiehCheng,
Lin YuChing,
SohChing NG,
Wang JongShyan,
Yeh ChiHsiao
Publication year - 2017
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.31.1_supplement.839.13
Subject(s) - medicine , hemodynamics , cardiology , peripheral , arterial disease , brachial artery , blood flow , blood pressure , vascular disease
Peripheral arterial disease (PAD) causes chronic narrowing of arteries and reduces the capacity of blood flow to the legs, which can progress in severity to greatly limit mobility in the patients. What kind of exercise test serves as a functional indicator of PAD progression needs for further investigation. Sixty‐four patients with PAD were recruited and subsequently performed three exercise tests [6 minutes walking test (6MWT), 3 minutes stepping test (3MST) and cardiopulmonary exercise test on a bicycle ergometer (CPET)]. Magnetic resonance angiography (MRA) was adopted to measure hemodynamic characteristics, whereas sphygmomanometry and duplex ultrasonography were employed to assess arterial brachial index (ABI). The results demonstrated that the values of ABI were associated with the levels of blood flow in posterior tibial artery/peroneal artery/femoral artery, but not relative to the measures of CPET, 6MWT or 3MST. However, the initial pain time in CPET or 3MST was associated with the initial pain distance of 6MWT. Additionally, functional parameters of CPET and 6MWT were positively correlated with hemodynamic parameters of MRA. Therefore, we conclude that functional parameters obtained from 6MWT and CPET effectively predict hemodynamic characteristics in patients with PAD. Support or Funding Information Chang Gung Memorial Hospital, Keelung, Taiwan (CMRPG2F0191)Ministry of Science and Technology, Taiwan (105‐2314‐B‐182A‐130‐)