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Influence of Body Fat Distribution in Autonomic Dysfunction of Young Obese Women
Author(s) -
Vicente Wanda Rafaela Pinto Lopes,
Fonseca Felipe Xerez Cepêda,
Silva Leslie Virmondes,
Hussid Maria Fernanda,
Corso Simone Dal,
De Angelis Katia,
Paula Vieira Rodolfo,
Lopes Heno Ferreira,
ConsolimColombo Fernanda Marciano,
Tinucci Taís,
Trombetta Ivani Credidio
Publication year - 2017
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.31.1_supplement.838.2
Subject(s) - waist , medicine , obesity , heart rate , endocrinology , waist–hip ratio , anthropometry , abdominal obesity , cardiology , blood pressure
Obesity impairs autonomic control with an adverse effect on cardiovascular risk. The association of obesity and autonomic dysfunction seems to be dependent on the distribution of body fat. The evaluation of heart rate (HR) at rest and during exercise may reflect autonomic dysfunction. The aim of this study was to evaluate the modulation of HR at rest and during exercise and its association with the body fat distribution in obese young women. We selected 49 young obese women (BMI 30 to 40 kg/m 2 ) with waist circumference (WC) ≥ 88 cm and without comorbidities. They were divided into: with central fat distribution (CF), defined as waist‐to‐hip ratio (WHR) ≥ 0.85 cm (n=26, 34±1.4 y, 33.2±0,5 kg/m 2 ), and with peripheral fat distribution (PF) with WHR < 0.85 cm (n=23, 33±1.4 y, 33.6±0,5 kg/m 2 ). All volunteers were submitted to anthropometric and clinical assessment and to cardiopulmonary exercise test to assess the HR at rest; and changes from rest to peak exercise and during 6 min of recovery. Despite the fat distribution, CF and PF shown similar functional capacity (VO 2 peak, 18.4±0.5 vs . 17.9±0.8 mL/kg/min, respectively; p=0.66). However, CF and PF presented diminished functional capacity compared with the estimate functional capacity for similar age and sex (60±2 and 57±3%; p=0.46). Based in the cut‐off values that designated cardiovascular risk, i. e., rest HR >75 bpm and chronotropic reserve (peak HR – rest HR) <89 beats, both obese groups, CF and PF, presented elevated resting HR (89 [82–98] and 86 [81–97] bpm, respectively) and reduced chronotropic reserve (78±3 and 72±4 beats). Furthermore, the group CF (WHR ≥ 0.85) presented reduced attenuation of HR at 1st min of recovery compared with PF (14±1 vs . 20±2 beats, p=0.044). In conclusion, our data suggest that young obese women had impaired sympatho‐vagal balance, observed by resting HR and chronotropic reserve during maximal progressive exercise test. The central body fat distribution potentiates the vagal dysfunction, characterized by reduced attenuation of HR at 1st min of recovery after maximal exercise test.