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Steady State vs. Pulsatile Blood Pressure Component and Regional Cerebral Perfusion
Author(s) -
Laosiripisan Jitanan,
Haley Andreana P,
Tanaka Hirofumi
Publication year - 2017
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.31.1_supplement.836.13
Subject(s) - pulsatile flow , cerebral perfusion pressure , blood pressure , pulse pressure , cerebral blood flow , mean arterial pressure , cardiology , medicine , cerebral autoregulation , perfusion , anesthesia , heart rate , autoregulation
Arterial blood pressure can be divided into steady state component that is determined by mean arterial pressure and pulsatile component that is explored by pulse pressure. The brain is a region that has vascular bed with high blood flow and low vascular impedance, which is affected greatly by excessive and/or fluctuated blood pressure. Indeed high blood pressure is related to impaired cognitive function. In the present study, we aimed to determine the relationship between steady state and pulsatile blood pressure components and regional cerebral perfusion at 10 regions of interest. A total of 52 apparently healthy adults aged 40–60 years were studied. All the subjects had normal global cognitive function as assessed by the Mini‐Mental Status Exam score greater than 28. Regional cerebral perfusions were measured using arterial spin labeling technique in 10 a priori regions of interest. Correlational analyses revealed 5 regions that their cerebral perfusion values were significantly and inversely associated with blood pressure components (i.e., hippocampus, anterior white matter, posterior insula, central white matter, and occipitoparietal area). After controlling for potential confounding factors (i.e., age, sex, race, education, and BMI) in multiple regression analyses, however, significant associations were observed only in 3 regions (i.e., hippocampus, posterior insula, and occipitoparietal area). In general, the strengths of associations with regional cerebral perfusion were greater with pulse pressure than with mean arterial pressure. Central (carotid) pulse pressure did not record greater associations compared with peripheral (brachial) pulse pressure. In conclusion, pulsatile component of blood pressure was significantly and inversely related to regional cerebral perfusion in the areas that are affected by fluctuating blood pressure in apparently healthy adults with normal cognitive function.