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Exercise‐like mechanical stimulation improves myogenic responses in aged skeletal muscle resistance arteries
Author(s) -
Shin Song Yi,
Seawright John,
Trache Andreea,
Woodman Christopher
Publication year - 2017
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.31.1_supplement.835.9
Subject(s) - myogenic contraction , medicine , skeletal muscle , stimulation , vascular resistance , cardiology , constriction , blood pressure , anatomy , endocrinology , smooth muscle
Objective We tested the hypothesis that exposure to a short‐duration (1 h) increase in intraluminal pressure, to mimic pressure associated with a bout of exercise, would attenuate or reverse the age‐related decline in myogenic constrictor responses in skeletal muscle resistance arteries. Methods Soleus muscle feed arteries (SFA) from young (4 mo) and old (24 mo) Fischer 344 rats were cannulated and pressurized to 90 (P90) or 130 cmH 2 O (P130) for 1 h. Following the 1 h treatment period, pressure in the P130 arteries was reduced to 90 cmH 2 O and SFA were required to develop stable spontaneous tone for 10 min. After stable tone was achieved, myogenic contractile responses were assessed using step‐increases in intraluminal pressure up to 135 cm H 2 O in 15 cm H 2 O increments followed by step‐decreases down to 60 cm H 2 O. Results Myogenic vasoconstrictor responses were significantly impaired in old SFA compared to young SFA. Mechanical stimulation with increased pressure for 1 h improved myogenic constriction in old SFA. Conclusion These results indicate that stimulation with a short‐duration increase in intraluminal pressure, within a range of pressure believed to be present in these arteries during exercise, improves myogenic constrictor responses in aged skeletal muscle resistance arteries. Support or Funding Information Research support: AHA grant 0765043Y, AHA grant 4150031, The National Space Biomedical Research Institute through NCC 9–58 and a Sydney and J.L. Huffines Institute of Sports Medicine Graduate Student Research Grant.