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Haptoglobin prevents atherosclerosis by inflammation regulation: A prevention role of haptoglobin Hp for atherosclerosis
Author(s) -
Cheng TsaiMu,
Chu HsuehLiang,
Pan JuPin
Publication year - 2017
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.31.1_supplement.825.1
Subject(s) - inflammation , haptoglobin , angiogenesis , immunology , medicine , cell adhesion molecule , monocyte , endothelial stem cell , cancer research , biology , in vitro , biochemistry
Coronary artery disease is the leading cause death all over the world. Dysfunction of the endothelial cells in blood vessels is one of the major events in the development of atherosclerosis. Inflammation involve in the initiative of atherosclerotic lesion process. In the progression, monocytes recruitment contributes to the early stage of atherosclerosis. Oxidation stress is another remarkable proinflammatory factor will induce endothelial cell inflammation and stimulate monocytes recruitment and differentiated to resident macrophages in vascular wall. In this study, we estimate that haptoglobin have strong anti‐oxidant activity and decrease the differentiated adhesive monocytes amount in vitro. In addition, we find haptoglobin inhibit monocyte adhesion molecular vascular cell adhesion molecule 1 ( VCAM ‐ 1 ) and Intercellular Adhesion Molecule 1 (ICAM‐1) expression in PMA‐induced inflammation endothelial cells. According, haptoglobin has the abilities to prevent LDL oxidation to mm‐LDL and ox‐LDL and decrease inflammation driven monocyte recruitment and differentiate into resident macrophages in vascular wall intimal space. Furthermore, we find haptoglobin enhance human umbilical vein endothelial cells (HUVECs) proliferation, migration, and angiogenesis in vitro . The abilities can accelerate wound healing process in the oxidative and inflammation initiated atherosclerotic lesion and improve cardiomyocyte function in ischemic damaged lesion. Currently, anti‐oxidant, anti‐inflammation, and angiogenesis enhance agents are the major studies trend for coronary artery diseases therapeutic application. In this study, we find haptoglobin has the activities to prevent atherosclerotic process and to improve functional activities in damaged atherosclerotic lesion. In conclusion, haptoglobin has strong potential as a protein drug for atherosclerosis prevention and therapeutic application. Support or Funding Information This work was supported by the grants MOST 105‐2314‐B‐038‐016 and MOST 105‐2119‐M‐038‐001 from Ministry of Science and Technology, Taiwan.