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&[Beta]ETA‐CYCLODEXTRIN‐COMPLEXED WITH LIPPIA GRATA LEAVES ESSENTIAL OIL REDUCES HYPERALGESIA IN MICE
Author(s) -
Quintans Jullyana Siqueira,
SiqueiraLima Pollyana,
Menezes Erik Pereira,
Filho Heitor Gomes Araújo,
Araujo Adriano,
Rezende Marilia M,
Amarante Ruthy Kellen Lima,
Souza Barreto Rosana,
Lucchese Angelica,
Quintans Lucindo José
Publication year - 2017
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.31.1_supplement.812.14
Subject(s) - pharmacology , analgesic , essential oil , neuropathic pain , eugenol , medicine , hyperalgesia , anesthesia , pleural cavity , lippia , antispasmodic , cyclodextrin , chemistry , traditional medicine , surgery , biochemistry , organic chemistry , chromatography , nociception , receptor
Lippia grata Schauer is a medicinal plant native of the semi‐arid area of Northeastern Brazil used in folk medicine as analgesic, anti‐inflammatory and antispasmodic. The leaf essential oil (EO) obtained from L. grata is rich in camphor, (E)‐caryophyllene, bicyclogemacrene, camphene and borneol which has already demonstrated analgesic profile. The pharmacological uses of EO could be limited by short half‐life and insolubility in water but β‐cyclodextrin (CD) could be an effective tool to improve this. Thus, we assessed the pharmacological profile of EO and EO complexed with CD (CDEO) in a model of neuropathic pain induced by injury of the sciatic nerve and in an inflammatory model (pleurisy model) in mice. All experiments were approved by the Animal and Use Committee of the Federal University of Sergipe (CEPA/UFS# 65/2015). Mice were pretreated with EO and CDEO (24 mg/kg, orally route) or vehicle at 7 days after surgery and 1h before carrageenan pleural injection. The treatment with EO and CDEO were able to promote antihyperalgesic effect in mechanical (analgesymeter) and increase latency for thermal stimulation (hot plate test) (p< 0,001) when compared with control group. The treatment with EO or CDEO were effective in reducing the leukocyte influx to pleural cavity and also reduced levels (p < 0,001) of IL‐1beta and TNF‐alpha in the pleural lavage. Moreover, no motor abnormalities were observed after treatment with EO and CDEO. Our findings demonstrated that EO and CDEO possess an analgesic and anti‐inflammatory profile in neuropathic pain and inflammatory models respectively, which seems to be involved by reduction of pro‐inflammatory cytokines. Support or Funding Information CNPq, CAPES, FAPITEC‐SE, FINEP

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